A Randomized Study Comparing the Short-Term Neurocognitive Outcome of Electroconvulsive Therapy Versus Repetitive Transcranial Magnetic Stimulation in the Treatment of Patients With Depression
| Autor: | Suaad Moussa, Nagwan Madbouly, Mye A. Basheer, Ahmed Fouad AbdEl Latif, Adly Elsheikh, Mohamed Nasreldin, Heba Fathy, Ann A Abdel Kader |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Prefrontal Cortex Audiology Neuropsychological Tests behavioral disciplines and activities law.invention 03 medical and health sciences 0302 clinical medicine Electroconvulsive therapy Cognition Randomized controlled trial law mental disorders medicine Memory span Humans Electroconvulsive Therapy Depressive Disorder Major business.industry Wechsler Adult Intelligence Scale medicine.disease Transcranial Magnetic Stimulation 030227 psychiatry Transcranial magnetic stimulation Treatment Outcome Major depressive disorder Egypt Female business Neurocognitive psychological phenomena and processes 030217 neurology & neurosurgery Stroop effect |
| Zdroj: | Journal of psychiatric practice. 26(1) |
| ISSN: | 1538-1145 |
| Popis: | Background Studies have compared electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS) with regard to their clinical efficacy in the treatment of depression, but only a few studies have addressed their differential impact on cognition. The purpose of this study was to compare the neurocognitive side effects of both treatment modalities. Methods In this comparative study, 40 patients with major depressive disorder referred for ECT were randomly assigned either to a course of 25 sessions of rTMS to the left dorsolateral prefrontal cortex or to a course of ECT ranging from 4 to 8 sessions. The primary outcome measures were the results of a cognitive battery that assessed different aspects of cognitive functioning. The cognitive battery comprised the Digit Span Subtest from the Wechsler Adult Intelligence Scale, the Stroop Color-Word Test-Victoria version, the Color Trails Test Trials 1 and 2, and the Rey-Osterrieth Complex Figure Test. Results At the end of treatment, scores on the Digit Span Subtest, the Stroop Color-Word Test-Victoria version, and the Color Trails Test showed statistically significant better results in the rTMS group compared with the ECT group. Conclusions rTMS was well tolerated with less negative impact on cognitive functioning than ECT. |
| Databáze: | OpenAIRE |
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