OntoRepliCov: an Ontology-Based Approach for Modeling the SARS-CoV-2 Replication Process
| Autor: | Isabelle Imbert, Wissame Laddada, India L'Hote, Lina Fatima Soualmia, Cecilia Zanni-Merk, Ali Ayadi, Claudia Frydman |
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| Přispěvatelé: | Modèles et Formalismes à Evénements Discrets (MOFED), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Architecture et fonction des macromolécules biologiques (AFMB), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire d'Informatique, du Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Normandie Université (NU), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2021 |
| Předmět: |
Knowledge representation and reasoning
Process (engineering) Computer science media_common.quotation_subject Context (language use) Ontology (information science) computer.software_genre Article [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] biology domain [INFO]Computer Science [cs] Function (engineering) SWRL ComputingMilieux_MISCELLANEOUS General Environmental Science media_common Semantic Web Rule Language business.industry reasoning process SWRL Knowledge representation [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation Replication (computing) Knowledge representation General Earth and Planetary Sciences Semantic technology Artificial intelligence [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] business computer Natural language processing |
| Zdroj: | KES Procedia Computer Science Procedia Computer Science, Elsevier, 2021, 192, pp.487-496. ⟨10.1016/j.procs.2021.08.050⟩ Knowledge-Based and Intelligent Information & Engineering Systems: Proceedings of the 25th International Conference KES2021 Knowledge-Based and Intelligent Information & Engineering Systems: Proceedings of the 25th International Conference KES2021, Sep 2021, Szczecin, Poland, Poland. pp.487-496, ⟨10.1016/j.procs.2021.08.050⟩ Procedia Computer Science, 2021, 192, pp.487-496. ⟨10.1016/j.procs.2021.08.050⟩ KES, Sep 2021, Szczecin, Poland. pp.487-496, ⟨10.1016/j.procs.2021.08.050⟩ |
| ISSN: | 1877-0509 |
| Popis: | Communication au congrès KES de 2021 qui s'est déroulé à Szczecin; International audience; Understanding the replication machinery of viruses contributes to suggest and try effective antiviral strategies. Exhaustive knowledge about the proteins structure, their function, or their interaction is one of the preconditions for successfully modeling it. In this context, modeling methods based on a formal representation with a high semantic expressiveness would be relevant to extract proteins and their nucleotide or amino acid sequences as an element from the replication process. Consequently, our approach relies on the use of semantic technologies to design the SARS-CoV-2 replication machinery. This provides the ability to infer new knowledge related to each step of the virus replication. More specifically, we developed an ontology-based approach enriched with reasoning process of a complete replication machinery process for SARS-CoV-2. We present in this paper a partial overview of our ontology OntoRepliCov to describe one step of this process, namely, the continuous translation or protein synthesis, through classes, properties, axioms, and SWRL (Semantic Web Rule Language) rules. |
| Databáze: | OpenAIRE |
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