miR-143 Inhibits NSCLC Cell Growth and Metastasis by Targeting Limk1
| Autor: | Shengjie Sun, Daliang Qi, Hui Xia, Guo Li, Chaoyang Liang, Bo Wang, Xiangyang Chu, Tao Wang, Chongbiao Huang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
proliferation
Apoptosis LIMK1 Biology NSCLC migration medicine.disease_cause Article Catalysis Metastasis lcsh:Chemistry Inorganic Chemistry Carcinoma Non-Small-Cell Lung Cell Line Tumor microRNA medicine Humans Physical and Theoretical Chemistry lcsh:QH301-705.5 neoplasms Molecular Biology Spectroscopy Cell Proliferation Limk1 Cell growth Kinase Organic Chemistry Lim Kinases General Medicine invasion medicine.disease miR-143 respiratory tract diseases Computer Science Applications Cell biology MicroRNAs lcsh:Biology (General) lcsh:QD1-999 Tumor progression Cancer research Carcinogenesis |
| Zdroj: | International Journal of Molecular Sciences, Vol 15, Iss 7, Pp 11973-11983 (2014) International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 15; Issue 7; Pages: 11973-11983 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms150711973 |
| Popis: | MicroRNAs (miRNAs) have essential roles in carcinogenesis and tumor progression. Here, we investigated the roles and mechanisms of miR-143 in non-small cell lung cancer (NSCLC). miR-143 was significantly decreased in NSCLC tissues and cell lines. Overexpression of miR-143 suppressed NSCLC cell proliferation, induced apoptosis, and inhibited migration and invasion in vitro. Integrated analysis identified LIM domain kinase 1 (Limk1) as a direct and functional target of miR-143. Overexpression of Limk1 attenuated the tumor suppressive effects of miR-143 in NSCLC cells. Moreover, miR-143 was inversely correlated with Limk1 expression in NSCLC tissues. Together, our results highlight the significance of miR-143 and Limk1 in the development and progression of NSCLC. |
| Databáze: | OpenAIRE |
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