Pinhole Versus Parallel-Hole Collimators for Parathyroid Imaging: An Intraindividual Comparison
| Autor: | Maria B. Tomas, Charito Love, Gene Tronco, Paul Pugliese, Christopher J. Palestro, Kenneth Nichols |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Technetium Tc 99m Sestamibi medicine.medical_specialty Scintigraphy Sensitivity and Specificity Lesion Parathyroid imaging medicine Humans Radiology Nuclear Medicine and imaging Intraindividual comparison Tomography Emission-Computed Single-Photon Radiological and Ultrasound Technology Lesion detection medicine.diagnostic_test business.industry Hyperparathyroidism Reproducibility of Results Equipment Design General Medicine Middle Aged Image Enhancement medicine.disease Equipment Failure Analysis Parathyroid Neoplasms Female Pinhole (optics) Radiology Radiopharmaceuticals medicine.symptom Nuclear medicine business Pinhole collimator Primary hyperparathyroidism |
| Zdroj: | Journal of Nuclear Medicine Technology. 36:189-194 |
| ISSN: | 0091-4916 |
| Popis: | Thisstudywasundertakentodeterminetheeffectsofcollimators on the accuracy of preoperative sestamibi parathyroid imaging of the neck. Methods: Forty-nine patients with primary hyperparathyroidism underwent preoperative 99m Tc-sestamibi parathyroid imaging. The protocol included early and late pinhole and parallel-hole imaging. One experienced nuclear physician, without knowledge of other test results or final diagnoses, interpretedstudies. Forbothpinholeandparallel-hole images,focally increased sestamibi accumulation outside the normal tracer biodistribution that persisted or increased in intensity from early to late images was interpreted as positive for a parathyroid lesion. Final diagnoses were operatively confirmed in all patients. Results: Fifty-four parathyroid lesions were resected from the 49 patients. Forty-five patients had single-gland disease. Four patients had multigland disease: 3 had 2 lesions and 1 had 3 lesions. Median lesion weight was 840 mg. Pinhole imaging was significantly more sensitive than parallel-hole imaging (89% vs. 56%; P 5 0.0003) for all 54 lesions. Specificity did not significantly differ between pinhole and parallel-hole imaging (93% vs. 96%, P 5 0.29). Pinhole imaging was significantly more sensitive than parallel-hole imaging for lesions above (100% vs. 68%, P 5 0.003) and below (77% vs. 42%, P 5 0.03) the median weight and for single-gland disease (96% vs. 67%, P 5 0.001). Pinhole imaging also was more sensitive for multigland disease, although the difference was only marginally significant (55% vs. 0%, P 5 0.037). Conclusion: Because sensitivity is significantly higher, sestamibi parathyroid imaging of the neck should be performed with a pinhole collimator. |
| Databáze: | OpenAIRE |
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