Relation of Resting Heart Rate to Prognosis in Patients With Idiopathic Pulmonary Arterial Hypertension
| Autor: | Martin J. Schalij, Anco Boonstra, Hubert W. Vliegen, Cees A. Swenne, C. Tji-Joong Gan, Serge A. van Wolferen, Ivo R. Henkens, Ernst E. van der Wall, Anton Vonk-Noordegraaf, Jos W. R. Twisk, Otto Kamp |
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| Přispěvatelé: | Pulmonary medicine, Cardiology, ICaR - Heartfailure and pulmonary arterial hypertension, EMGO - Lifestyle, overweight and diabetes, Methodology and Applied Biostatistics, EMGO+ - Lifestyle, Overweight and Diabetes |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Hypertension Pulmonary medicine.medical_treatment Hemodynamics Electrocardiography SDG 3 - Good Health and Well-being Heart Rate Predictive Value of Tests Internal medicine Heart rate medicine Humans Lung transplantation Proportional Hazards Models Retrospective Studies Chi-Square Distribution business.industry Respiratory disease Hazard ratio Middle Aged Prognosis medicine.disease Pulmonary hypertension Confidence interval Survival Rate ROC Curve Heart failure Exercise Test Cardiology Female Cardiology and Cardiovascular Medicine business Lung Transplantation |
| Zdroj: | Henkens, I R, van Wolferen, S A, Gan, C T, Boonstra, A, Swenne, C A, Twisk, J W R, Kamp, O, van der Wall, E E, Schalij, M J, Vonk noordegraaf, A & Vliegen, H W 2009, ' Relation of Resting Heart Rate to Prognosis in Patients With Idiopathic Pulmonary Arterial Hypertension ', American Journal of Cardiology, vol. 103, no. 10, pp. 1451-1456 . https://doi.org/10.1016/j.amjcard.2009.01.359 American Journal of Cardiology, 103(10), 1451-1456. Elsevier Inc. |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/j.amjcard.2009.01.359 |
| Popis: | Heart rate (HR) at rest is an important marker of prognosis in heart failure, but has not been addressed in pulmonary arterial hypertension (PAH). To determine the prognostic value of HR at rest in patients with PAH, we retrospectively analyzed 140 consecutive patients with idiopathic PAH. Electrocardiogram (ECG)-derived HR at rest was evaluated as a potential predictor of adverse prognosis (death or lung transplantation), in addition to World Health Organization functional class, 6-minute walk distance, and hemodynamics before and approximately 1 year and 2 years after initiation of PAH treatment. During follow-up, 49 patients (35%) died, and 5 patients (4%) underwent lung transplantation. Before treatment initiation and after 1 year and 2 years of treatment, respectively, a higher HR at rest was an independent predictor of adverse prognosis (hazard ratios per 10-beats/min increase 1.76, 95% confidence interval 1.42 to 2.18, 2.31, 95% confidence interval 1.58 to 3.38, 2.1, 95% confidence interval 1.39 to 3.19, respectively, p |
| Databáze: | OpenAIRE |
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