Ovarian Epithelioid Trophoblastic Tumor in a Cynomolgus Monkey
| Autor: | M. L. Carcangiu, Eugenio Scanziani, A. M. Giusti, A. Terron, Sara Belluco |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Pathology Lung Neoplasms 040301 veterinary sciences Trophoblastic Tumor Ovary Syncytiotrophoblasts Trophoblastic Neoplasms Biology 0403 veterinary science Multinucleate Pregnancy Internal medicine medicine Animals 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Epithelioid Trophoblastic Tumor reproductive and urinary physiology Ovarian Neoplasms General Veterinary Intermediate trophoblast Monkey Diseases 05 social sciences 04 agricultural and veterinary sciences medicine.disease Macaca fascicularis Endocrinology medicine.anatomical_structure Placental alkaline phosphatase embryonic structures Female Epithelioid cell |
| Zdroj: | Veterinary Pathology. 42:223-226 |
| ISSN: | 1544-2217 0300-9858 |
| Popis: | Epithelioid trophoblastic tumor (ETT) is an unusual type of trophoblastic tumor, with features resembling carcinoma. In this study, we describe a 4-year-old cynomolgus monkey ( Macaca fascicularis) showing, at necropsy, a lobulated mass replacing the left ovary and several nodular lesions within the lungs. Histologically, the mass in the ovary and lung metastases were characterized by nests of epithelioid cells, with intermingled, occasional, multinucleate tumor cells consistent with syncytiotrophoblasts and moderate amount of eosinophilic, hyaline-like material. Immunohistochemically, the tumor cells were diffusely positive for cytokeratins (AE1/AE3) and inhibin-α, but only focal immunoreactivity was observed for human chorionic gonadotropin, whereas placental alkaline phosphatase was always negative. On the basis of morphology and immunohistochemical reactivity, tumor cells were identified as intermediate trophoblast. |
| Databáze: | OpenAIRE |
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