A case of nasal low-grade non-intestinal-type adenocarcinoma with aberrant CDX2 expression and a novel SYN2-PPARG gene fusion in a 13-year-old girl

Autor:	Chik Hong Kuick, Gwyneth Soon, Kenneth Tou En Chang, Fredrik Petersson
Rok vydání:	2019
Předmět:	0301 basic medicine Nasal cavity Pathology medicine.medical_specialty Adolescent media_common.quotation_subject Adenocarcinoma Pathology and Forensic Medicine Fusion gene 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor medicine Nasal septum Humans Intestinal type adenocarcinoma CDX2 Transcription Factor Girl CDX2 Molecular Biology media_common Homeodomain Proteins business.industry Cell Biology General Medicine medicine.disease Immunohistochemistry PPAR gamma 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Female Gene Fusion Nasal Cavity business PPARG gene Paranasal Sinus Neoplasms
Zdroj:	Virchows Archiv. 474:619-623
ISSN:	1432-2307 0945-6317
DOI:	10.1007/s00428-019-02524-w
Popis:	We report the first patient (a 13-year-old girl) with a sinonasal low-grade non-intestinal-type adenocarcinoma showing aberrant CDX2 expression both within morular areas and in the tubular component and demonstrate for the first time a SYN2-PPARG gene fusion in this tumor type. The tumor arose from the nasal septum and had not spread beyond the nasal cavity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babe147f89711e017b76db847fe0b2ca https://doi.org/10.1007/s00428-019-02524-w Zobrazit plný text záznamu Full text from SpringerLink