Optical coherence tomography and electrophysiology of retinal and visual pathways in Wilson’s disease
| Autor: | Ewa Langwińska-Wośko, Anna Członkowska, Tomasz Litwin, Kamil Szulborski |
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| Rok vydání: | 2015 |
| Předmět: |
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medicine.medical_specialty Pathology Neurology genetic structures Wilson’s disease Clinical Neurology Nerve fiber layer Visual system Biochemistry Retina 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound Nerve Fibers 0302 clinical medicine Hepatolenticular Degeneration Optical coherence tomography Electroretinography medicine Humans Visual Pathways Pattern-reversal visual evoked potentials medicine.diagnostic_test Retinal medicine.disease Wilson's disease medicine.anatomical_structure chemistry Brain magnetic resonance 030221 ophthalmology & optometry Evoked Potentials Visual Female Original Article sense organs Neurology (clinical) Psychology Tomography Optical Coherence 030217 neurology & neurosurgery |
| Zdroj: | Metabolic Brain Disease |
| ISSN: | 1573-7365 0885-7490 |
| DOI: | 10.1007/s11011-015-9776-8 |
| Popis: | We evaluated correlations between positive findings of changes on brain magnetic resonance imaging (MRI) and selected morphological and electrophysiological parameters of the retinal and visual systems in Wilson’s disease. Fifty-eight Wilson’s disease symptomatic patients were divided according to whether they displayed brain changes on MRI (positive, n = 39; negative, n = 19). All participants and healthy control group (n = 30), underwent retinal optical coherence tomography to assess the thickness of macula and the total retinal nerve fiber layer. Visual evoked potentials were measured and electroretinography was performed. Macular and retinal nerve fibers were thinner in participants with changes on MRI than in participants without changes. Electrophysiological parameters were markedly different in the MRI positive group compared with the negative group and 30 healthy controls; however, some abnormalities were evident in cases without visible brain pathology. Morphological and electrophysiological changes of retinal and visual pathways are associated with MRI visualized brain injury in Wilson’s disease and may be useful for detecting the degree of neurodegeneration. |
| Databáze: | OpenAIRE |
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