Recent Advances in Hydrogels: Ophthalmic Applications in Cell Delivery, Vitreous Substitutes, and Ocular Adhesives
| Autor: | Athena Wang, Janaki Iyer, Alexandra B. Nguyen, Kenny T. Lin, Simon D. Tran |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
ocular adhesives
medicine.medical_specialty genetic structures QH301-705.5 medicine.medical_treatment Medicine (miscellaneous) vitreous substitutes Vitrectomy 02 engineering and technology Review General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cataracts stem cells Ophthalmology medicine Biology (General) Retina Retinal pigment epithelium business.industry Retinal Diabetic retinopathy 021001 nanoscience & nanotechnology medicine.disease eye diseases 3. Good health Transplantation medicine.anatomical_structure retinal diseases chemistry Self-healing hydrogels cataracts 030221 ophthalmology & optometry sense organs hydrogel 0210 nano-technology business |
| Zdroj: | Biomedicines Biomedicines, Vol 9, Iss 1203, p 1203 (2021) |
| ISSN: | 2227-9059 |
| Popis: | With the prevalence of eye diseases, such as cataracts, retinal degenerative diseases, and glaucoma, different treatments including lens replacement, vitrectomy, and stem cell transplantation have been developed; however, they are not without their respective shortcomings. For example, current methods to seal corneal incisions induced by cataract surgery, such as suturing and stromal hydration, are less than ideal due to the potential for surgically induced astigmatism or wound leakage. Vitrectomy performed on patients with diabetic retinopathy requires an artificial vitreous substitute, with current offerings having many shortcomings such as retinal toxicity. The use of stem cells has also been investigated in retinal degenerative diseases; however, an optimal delivery system is required for successful transplantation. The incorporation of hydrogels into ocular therapy has been a critical focus in overcoming the limitations of current treatments. Previous reviews have extensively documented the use of hydrogels in drug delivery; thus, the goal of this review is to discuss recent advances in hydrogel technology in surgical applications, including dendrimer and gelatin-based hydrogels for ocular adhesives and a variety of different polymers for vitreous substitutes, as well as recent advances in hydrogel-based retinal pigment epithelium (RPE) and retinal progenitor cell (RPC) delivery to the retina. |
| Databáze: | OpenAIRE |
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