Solid-Phase Synthesis of Oxetane Modified Peptides
| Autor: | Andrew G. Jamieson, Piotr Raubo, Michael Shipman, Astrid Knuhtsen, Alex Hoose, Jonathan D. Beadle |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
RM Dipeptide Molecular Structure 010405 organic chemistry Chemistry Peptidomimetic Organic Chemistry Peptide 010402 general chemistry Ring (chemistry) Oxetane 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound Solid-phase synthesis Ethers Cyclic Amide Peptide synthesis QD Physical and Theoretical Chemistry Peptides Solid-Phase Synthesis Techniques |
| Zdroj: | Organic Letters. 19:3303-3306 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | Solid-phase peptide synthesis (SPPS) is used to create peptidomimetics in which one of the backbone amide C=O bonds is replaced by a four-membered oxetane ring. The oxetane containing dipeptide building blocks are made in three steps in solution, then integrated into peptide chains by conventional Fmoc SPPS. This methodology is used to make a range of peptides in high purity including backbone modified derivatives of the nonapeptide bradykinin and Met- and Leu-enkephalin.\ud |
| Databáze: | OpenAIRE |
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