Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta

Autor: Gabriela Inés Marino, Basilio Aristides Kotsias
Rok vydání: 2013
Předmět:
Epithelial sodium channel
medicine.medical_specialty
CIENCIAS MÉDICAS Y DE LA SALUD
Placenta
Biology
SYNCYTIOTROPHOBLAST
Preeclampsia
Amiloride
chemistry.chemical_compound
Syncytiotrophoblast
Pre-Eclampsia
Pregnancy
Internal medicine
Epithelial Sodium Channel Blockers
medicine
Humans
Epithelial Sodium Channels
Aldosterone
reproductive and urinary physiology
Ion transporter
WESTERN BLOT
IMMUNOSTAINING
urogenital system
HUMAN PLACENTA
ENAC
Obstetrics and Gynecology
Bioquímica y Biología Molecular
respiratory system
medicine.disease
Immunohistochemistry
Epithelial sodium channel blocker
PREECLAMPSIA
Medicina Básica
Protein Subunits
medicine.anatomical_structure
Endocrinology
Reproductive Medicine
chemistry
Case-Control Studies
embryonic structures
Female
hormones
hormone substitutes
and hormone antagonists
Developmental Biology
medicine.drug
Zdroj: Placenta. 34:197-200
ISSN: 0143-4004
DOI: 10.1016/j.placenta.2012.11.008
Popis: Aldosterone modulates the activity of the epithelial sodium channel (ENaC) through changes in its trafficking, membrane expression and open probability. Plasma levels of aldosterone are decreased in preeclampsia. Herein we postulated that if aldosterone regulates ENaC expression then its expression should be decreased in preeclampsia. We found a diminished expression of the three subunits of the ENaC in the membranes of preeclamptic placentas in comparison with the normal ones. Although the role of ENaC in placental tissues is poorly understood, these differences may have consequences for the ion transport involved in the pathophysiology of preeclampsia. Fil: Marino, Gabriela Inés. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires; Argentina Fil: Kotsias, Basilio Aristides. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires; Argentina
Databáze: OpenAIRE
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