Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit

Autor:	Vyom Shukla, Daniel M. Brody, Kristopher E. Boyle, Dale L. Boger, Prem B. Chanda
Rok vydání:	2016
Předmět:	Indoles Stereochemistry Protein subunit Clinical Biochemistry Pharmaceutical Science Stereoisomerism Alkylation 010402 general chemistry 01 natural sciences Biochemistry Article chemistry.chemical_compound Duocarmycins Mice Cell Line Tumor Drug Discovery Imidazole Animals Pyrroles Carboxylate Molecular Biology Duocarmycin Pyrrole Cell Proliferation Molecular Structure 010405 organic chemistry Organic Chemistry Imidazoles 0104 chemical sciences DNA Alkylation chemistry Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry. 24(20)
ISSN:	1464-3391
Popis:	The design, synthesis, and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) derivatives are detailed representing analogs of duocarmycin SA and yatakemycin containing an imidazole replacement for the fused pyrrole found in the DNA alkylation subunit.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab8b7046a1bf14edaf16e6d4d790948 https://pubmed.ncbi.nlm.nih.gov/27221071 Zobrazit plný text záznamu Full Text from ScienceDirect