Nutrient conditions sensed by the reproductive organ during development optimize male fecundity inDrosophila
| Autor: | Kiichiro Taniguchi, Rumi Sakata-Niitsu, Ayuko Kubo, Ryunosuke Minami, Hideki Nakagoshi, Takashi Adachi-Yamada, Mirai Matsuka, Fumika Kimura, Akihiko Kokuryo |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine media_common.quotation_subject Cell Fertility Biology Oogenesis 03 medical and health sciences Nutrient Semen Gene expression Genetics medicine Animals Drosophila Proteins Insulin Genitalia Transcription factor media_common Homeodomain Proteins Gene Expression Regulation Developmental Proventriculus Cell Biology Fecundity Cell biology 030104 developmental biology medicine.anatomical_structure Animal Nutritional Physiological Phenomena Drosophila Signal Transduction Transcription Factors |
| Zdroj: | Genes to Cells. 23:557-567 |
| ISSN: | 1356-9597 |
| DOI: | 10.1111/gtc.12600 |
| Popis: | Nutrient conditions affect the reproductive potential and lifespan of many organisms through the insulin signaling pathway. Although this is well characterized in female oogenesis, nutrient-dependent regulation of fertility/fecundity in males is not known. Seminal fluid components synthesized in the accessory gland are required for high fecundity in Drosophila males. The accessory gland is composed of two types of binucleated cells: a main cell and a secondary cell (SC). The transcription factors Defective proventriculus (Dve) and Abdominal-B (Abd-B) are strongly expressed in adult SCs, whose functions are essential for male fecundity. We found that gene expression of both Dve and Abd-B was down-regulated under nutrient-poor conditions. In addition, nutrient conditions during the pupal stage affected the size and number of SCs. These morphological changes clearly correlated with fecundity, suggesting that SCs act as nutrient sensors. Here, we provide evidence that Dve associates nutrient conditions with optimal reproductive potential in a target of rapamycin signaling-dependent manner. |
| Databáze: | OpenAIRE |
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