Effect of extracellular Mg2+ concentration on agonist-induced cytosolic free Ca2+ transients
| Autor: | Claus Spieker, Martin Tepel, Walter Zidek, Zhiming Zhu |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Agonist
inorganic chemicals Male medicine.medical_specialty Vascular smooth muscle Thapsigargin Arginine Fura-2 medicine.drug_class Biology Rats Inbred WKY Muscle Smooth Vascular Cytosolic free Ca2+ concentration chemistry.chemical_compound Cytosol Internal medicine medicine Extracellular Animals Magnesium Molecular Biology Cells Cultured Dose-Response Relationship Drug Terpenes Angiotensin II Cell Biology Rats Arginine Vasopressin Endocrinology chemistry Calcium |
| Zdroj: | Biochimica et biophysica acta. 1265(1) |
| ISSN: | 0006-3002 |
| Popis: | The modulating effects of extracellular Mg2+ concentration ([Mg2+]o) on vascular contraction are well known. In the present study it was tested how the changes in cytosolic free Ca2+ concentration ([Ca2+]i) induced by various agonists are modified by changes in [Mg2+]o. Extracellular Mg2+ deprivation increased the [Ca2+]i response to arginine vasopressin, to angiotensin II and to thapsigargin, but not to 5-hydroxytryptamine and noradrenaline. Withdrawal of extracellular Ca2+ revealed that extracellular Mg2+ deprivation increased Ca2+ influx, but not Ca2+ release from cellular stores. The findings demonstrate that different responses of [Ca2+]i to agonists may underlie the modulating effect of [Mg2+]o on vascular contraction. |
| Databáze: | OpenAIRE |
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