Expression of the highly conserved RNA binding protein KOC in embryogenesis
| Autor: | Barbara S. Pohl, Monika Wilda, Thomas M. Gress, Christine Wallrapp, Walter Knöchel, Michael Beil, Guido Adler, Horst Hameister, Friederike Mueller-Pillasch, U. Lacher |
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| Rok vydání: | 1999 |
| Předmět: |
Embryology
Embryo Nonmammalian RNA localization Xenopus 5.8S ribosomal RNA RNA-binding protein Xenopus Proteins Mice Transforming Growth Factor beta Animals Humans Signal recognition particle RNA Amino Acid Sequence Gene Pancreas Conserved Sequence Glycoproteins biology Hepatology Chemistry Embryogenesis Gastroenterology RNA Brain Gene Expression Regulation Developmental RNA-Binding Proteins Embryo Protein superfamily biology.organism_classification Non-coding RNA Molecular biology KH domain Cell biology Neoplasm Proteins RNA editing Developmental Biology |
| Zdroj: | Mechanisms of development. 88(1) |
| ISSN: | 0925-4773 |
| Popis: | The human KOC gene which is highly expressed in cancer shows typical structural features of an RNA binding protein. We analyzed the temporal and spatial expression pattern of KOC in mouse embryos at different gestational ages. The expression of KOC seems to be ubiquitous at early stages. During advanced gestation highest KOC expression occurs in the gut, pancreas, kidney, and in the developing brain. The expression pattern of KOC was compared to its Xenopus homologue Vg1-RBP during frog development. Similar expression was found in these organs suggesting an important functional role of the homologous proteins in embryonic development. |
| Databáze: | OpenAIRE |
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