Anacardic Acid Complexes as Possible Agents Against Alzheimer's Disease Through Their Antioxidant, In vitro, and In silico Anticholinesterase and Ansiolic Actions
| Autor: | Daniela Ribeiro Alves, Emmanuel Silva Marinho, Francisco Ernani Alves Magalhães, Selene Maia de Morais, Francisca Crislândia Oliveira Silva, Márcia Machado Marinho, Solange de Oliveira Pinheiro, Jane Eire Silva Alencar de Menezes, Wildson Max Barbosa da Silva |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.drug_class In silico medicine.medical_treatment Pharmacology Toxicology Anxiolytic Antioxidants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Alzheimer Disease medicine Galantamine Animals Zebrafish Chelating Agents chemistry.chemical_classification Chemistry General Neuroscience Acetylcholinesterase Amino acid Anacardic Acids Molecular Docking Simulation Zinc 030104 developmental biology Enzyme Toxicity Cholinesterase Inhibitors 030217 neurology & neurosurgery Copper medicine.drug |
| Zdroj: | Neurotoxicity research. 39(2) |
| ISSN: | 1476-3524 |
| Popis: | The frequency of Alzheimer's disease (AD) is growing rapidly with longer life expectancy and the consequent increase of people with a high risk of neurodegenerative diseases. Anacardic acid (AA) has several pharmacological actions, such as antioxidants, anticholinesterase, and anti-inflammatory, which are related to the protection against aging disorders. Also, the metals copper and zinc are co-factors of antioxidant enzymes that can be associated with AA to improve brain-protective action. This study aimed to evaluate the potential of AA metal complexes using copper and zinc chelators to produce potential agents against Alzheimer's disease. For this purpose, Cu and Zn were linked to AA in the ratio of 1:1 in a basic medium. The complexes' formation was confirmed by ultraviolet and visible spectroscopy. The toxicity was evaluated in the zebrafish model, and other information related to AD was obtained using the zebrafish model of anxiety. AA-Zn and AA-Cu complexes showed better antioxidant action than free AA. In the anti-AChE activity, AA was like the AA-Cu complex. In models using adult zebrafish, no toxicity for AA complexes was found, and in the locomotor model, AA-Cu demonstrated possible anxiolytic action. In in silico experiments comparing AA and AA-Cu complex, the coupling energy with the enzyme was lower for the AA-Cu complex, showing better interaction, and also the distances of the active site amino acids with this complex were lower, similar to galantamine, the standard anti-AChE inhibitor. Thus, AA-Cu showed interesting results for more detailed study in experiments related to Alzheimer's disease. |
| Databáze: | OpenAIRE |
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