Transmitter metabolism in substantia nigra after inhibition of dopaminergic neurones by butyrolactone
| Autor: | Ruth Lienhart, Walter Lichtensteiger, Franz Hefti |
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| Rok vydání: | 1976 |
| Předmět: |
Male
medicine.medical_specialty Dopamine Stimulation Substantia nigra Mice 4-Butyrolactone Dopaminergic Cell Internal medicine medicine Animals Aromatic Amino Acid Decarboxylase Inhibitors Furans Nerve Endings Multidisciplinary Chemistry Dopaminergic Da metabolism Depolarization Metabolism Dendrites Rats Substantia Nigra Endocrinology nervous system medicine.drug |
| Zdroj: | Nature. 263(5575) |
| ISSN: | 0028-0836 |
| Popis: | DOPAMINERGIC nigrostriatal neurones have recently been found to contain dopamine (DA) also in their dendrites1. Certain observations suggest a release of transmitter from these dendrites: depolarisation by potassium ions induces a release of 3H-DA from incubated tissue slices of rat substantia nigra2, and stimulation of the median forebrain bundle increases 3,4-dihydroxyphenylacetic acid, a major metabolic of DA3, in the mesencephalic region containing dopaminergic cell bodies and dendrites4, as well as in caudate–putamen, the terminal area. These similarities between terminal and somato-dendritic areas point to a similar regulation of DA metabolism and an active role of DA in both parts of the neurone. We have studied this question in a situation where the dopaminergic neurones are inhibited. γ-Butyrolactone (GBL) applied systemically, strongly reduces unit activity of the dopaminergic neurones in zona compacta of substantia nigra5. Under these conditions, the changes observed in the somato–dendritic complex differed markedly from those reported for the terminal area6–12. |
| Databáze: | OpenAIRE |
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