Post-operative non-steroidal anti-inflammatory drug use for pain in infant and paediatric cardiac surgery patients
| Autor: | Dimitrios A. Savva, Jill A. Morgan, Omayma A. Kishk, Caroline Bauer, Hyunuk Seung, Jessica M Biggs |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Narcotic medicine.medical_treatment 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Quality of life Pain assessment Humans Medicine Cardiac Surgical Procedures Pain Measurement Retrospective Studies Pain Postoperative Maryland business.industry Incidence (epidemiology) Anti-Inflammatory Agents Non-Steroidal Infant General Medicine Analgesics Non-Narcotic Cardiac surgery Ketorolac Chest tube 030228 respiratory system Child Preschool Anesthesia Pediatrics Perinatology and Child Health FLACC scale Quality of Life Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiology in the Young. 29:1440-1444 |
| ISSN: | 1467-1107 1047-9511 |
| DOI: | 10.1017/s1047951119002312 |
| Popis: | Background:Pain control is an important element of care for patients after surgery, leading to better outcomes, quicker transitions to recovery, and improvement in quality of life. The purpose of this study was to evaluate the safety and efficacy of non-steroidal anti-inflammatory drugs in children after cardiac surgeryMaterials and Methods:Patients between the ages of 1 month and 18 years of age, who received intravenous or oral non-steroidal anti-inflammataory drugs after cardiac surgery, from November 2015 until September 2017 were included in this study. The primary endpoints were non-steroidal anti-inflammataory drug-associated renal dysfunction and post-operative bleeding. Secondary endpoints examined the effect of non-steroidal anti-inflammataory drug use on total daily dose of narcotics, number of intravenous PRN narcotic doses received, and pain assessment score. Data were analysed using descriptive statistics for frequencies and ranges. Multivariate analysis was performed to measure the association of all predictors and outcomes. Wilcoxon singed-rank test was performed for secondary outcomes.Results:There was no association between the incidence of renal dysfunction and the use of or duration of non-steroidal anti-inflammataory drugs; in addition no association was found with increased chest tube output. There was a statistically significant reduction of patients’ median Face, Legs, Activity, Cry, Consolability (FLACC) scores (2–0; p = 0.003), seen within first 24 hours after initiation of ketorolac, and a significant reduction of morphine requirements seen from day 1 to day 2 (0.3 mg/kg versus 0.1 mg/kg; p < 0.001) and number of as-needed doses.Conclusion:Non-steroidal anti-inflammataory drugs in paediatric cardiac surgery patients are safe and effective for post-operative pain management. |
| Databáze: | OpenAIRE |
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