Peptide Profile of Zebrafish Brain in a 6-OHDA-Induced Parkinson Model
| Autor: | Leandro M. Castro, Claudia Neves Correa, Louise Oliveira Fiametti |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2021 |
| Předmět: |
Peptide
Context (language use) Substantia nigra Biology neurodegenerative disease parasitic diseases Animals Cytoskeleton Oxidopamine Zebrafish mass spectrometry chemistry.chemical_classification Dopaminergic peptidomics Brain Lipid metabolism Parkinson Disease biology.organism_classification zebrafish Cytosol chemistry Animal Science and Zoology Peptides Neuroscience Developmental Biology |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1557-8542 |
| Popis: | Made available in DSpace on 2021-06-25T10:24:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-01 Parkinson's disease (PD) is a chronic neurodegenerative disorder mainly attributed to the progressive loss of dopaminergic neurons in the substantia nigra, which leads to uncontrolled voluntary movements causing tremors, postural instability, joint stiffness, and speech and locomotion difficulties, among other symptoms. Previous studies have shown the participation of specific peptides in neurodegenerative diseases. In this context, the present work analyzed changes in the peptide profile in zebrafish brain induced to parkinsonian conditions with 6-hydroxydopamine, using isotopic labeling techniques plus mass spectrometry. These analyses allowed the relative quantitation and identification of 118 peptides. Of these, nine peptides showed significant changes, one peptide was increased and eight decreased. The most altered sequences were fragment of cytosolic and extracellular proteins related to lipid metabolism and dynamic cytoskeleton. These results open new perspectives of study about the function of peptides in PD. Bioscience Institute Sao Paulo State University (UNESP) Biodiversity of Coastal Environments Postgraduate Program Bioscience Institute Sao Paulo State University (UNESP) Bioscience Institute Sao Paulo State University (UNESP) Biodiversity of Coastal Environments Postgraduate Program Bioscience Institute Sao Paulo State University (UNESP) |
| Databáze: | OpenAIRE |
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