Effect of epidural polydeoxyribonucleotide in a rat model of lumbar foraminal stenosis
| Autor: | Pyung Bok Lee, Francis Sahngun Nahm, Ghee Young Choe, Jiyoun Ju, Eun Joo Choi, Ho Jin Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Receptor
Adenosine A2A Spinal stenosis Injections Epidural Constriction Pathologic Constriction Lumbar Polydeoxyribonucleotides Spinal Stenosis Fibrosis medicine Radiculopathy Experimental Research Articles Inflammation business.industry medicine.disease Low back pain Anesthesiology and Pain Medicine Hyperalgesia Anesthesia Concomitant DMPX medicine.symptom Chronic Pain business Low Back Pain |
| Zdroj: | The Korean Journal of Pain |
| ISSN: | 2093-0569 2005-9159 |
| Popis: | Background We aimed to investigate the effect of epidural polydeoxyribonucleotide (PDRN) on mechanical allodynia and motor dysfunction in a rat model of lumbar foraminal stenosis (LFS). Methods This study was conducted in two stages, using male Sprague-Dawley rats. The rats were randomly divided into eight groups. In the first stage, the groups were as follows: vehicle (V), sham (S), and epidural PDRN at 5 (P5), 8 (P8), and 10 (P10) mg/kg; and in the second stage, they were as follows: intraperitoneal PDRN 8 mg/kg, epidural 3,7-dimethyl-1-propargilxanthine (DMPX) (0.1 mg/kg), and DMPX (0.1 mg/kg). The LFS model was established, except for the S group. After an epidural injection of the test solutions, von Frey and treadmill tests were conducted for 3 weeks. Subsequently, histopathologic examinations were conducted in the V, S, P5, and P10 groups. Results A total of 65 rats were included. The P8 and P10 groups showed significant recovery from mechanical allodynia and motor dysfunction at all time points after drug administration compared to the V group. These effects were abolished by concomitant administration of DMPX. On histopathological examination, no epineurial inflammation or fibrosis was observed in the epidural PDRN groups. Conclusions Epidural injection of PDRN significantly improves mechanical allodynia and motor dysfunction in a rat model of LFS, which is mediated by the spinal adenosine A2A receptor. The present data support the need for further research to determine the role of epidural PDRN in spinal stenosis treatment. |
| Databáze: | OpenAIRE |
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