Genetic control of polyketide biosynthesis in the genus Streptomyces
| Autor: | Krishna M. Madduri, C. R. Hutchinson, H. Decker, Li Tang, S. L. Otten |
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| Rok vydání: | 1993 |
| Předmět: |
Metabolite
Molecular Sequence Data Restriction Mapping Tylosin Microbiology Streptomyces Actinorhodin chemistry.chemical_compound Polyketide Lactones Biosynthesis Bacterial Proteins Consensus Sequence Operon Amino Acid Sequence Furans Molecular Biology Genetics biology Sequence Homology Amino Acid Streptomycetaceae Daunorubicin General Medicine biology.organism_classification Anti-Bacterial Agents chemistry Biochemistry Genes Bacterial Multigene Family Actinomycetales |
| Zdroj: | Antonie van Leeuwenhoek. 64(2) |
| ISSN: | 0003-6072 |
| Popis: | The genetic control of polyketide metabolite biosynthesis in Streptomyces sp. producing actinorhodin, daunorubicin, erythromycin, spiramycin, tetracenomycin and tylosin is reviewed. Several examples of positively-acting transcriptional regulators of polyketide metabolism are known, including some two-component sensor kinase-response regulator systems. Translational and posttranslational control mechanisms are only briefly mentioned since very little is known about either of these processes. Examples of how enzyme levels and substrate supply affect polyketide metabolism also are discussed. |
| Databáze: | OpenAIRE |
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