Corticosteroid Therapy in Neonatal Septic Shock-Do We Prevent Death?
| Autor: | Véronique Dorval, Myriam Vigny-Pau, Gabriel Altit, Anie Lapointe, Keith J. Barrington |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Inotrope
Male medicine.medical_specialty Hydrocortisone Hemodynamics Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Enterocolitis Necrotizing 030225 pediatrics Infant Mortality medicine Humans 030212 general & internal medicine Proportional Hazards Models Retrospective Studies Enterocolitis business.industry Septic shock Infant Newborn Obstetrics and Gynecology Infant medicine.disease Shock Septic Surgery Blood pressure Shock (circulatory) Anesthesia Bacteremia Pediatrics Perinatology and Child Health Necrotizing enterocolitis Female medicine.symptom business |
| Zdroj: | American journal of perinatology. 35(2) |
| ISSN: | 1098-8785 |
| Popis: | Objective The aim was to compare survival of patients with septic shock receiving or not hydrocortisone (HC) and to analyze the hemodynamic response to HC. Study Design It is a retrospective study of 62 premature neonates with septic shock (confirmed bacteremia) and/or necrotizing enterocolitis (NEC) stage 2 and above receiving inotropes with or without HC. We analyzed survival and hemodynamic response to HC. Results Thirty-nine (63%) premature neonates received HC and were compared with 23 (37%) who only received inotropes. Vasoactive index score (VAI) decreased and blood pressure, urine output, and oxygen requirements improved significantly following HC. Despite receiving more inotropes (VAI of 33 [20–53] vs 10 [8–20], p Conclusion HC was used in infants with increased inotropic support. HC during septic shock was associated with similar survival from episode, but with decreased survival at 1-year postmenstrual age. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|