Cryptosporidiosis and microsporidiosis as causes of diarrhea in kidney and/or pancreas transplant recipients
| Autor: | David Boutoille, F. Morio, B.M. Imbert, Maeva Lefebvre, François Raffi, M. Hourmant, P. Le Pape, C. Deltombe |
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| Přispěvatelé: | Institut de transplantation urologie-néphrologie (ITUN), Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire de parasitologie et de mycologie médicale [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Service de virologie [CHU Nantes], CCSD, Accord Elsevier |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Diarrhea Male medicine.medical_specialty medicine.medical_treatment Cryptosporidiosis Microsporidiosis Cohort Studies 03 medical and health sciences Immunocompromised Host Solid organ transplantation Internal medicine medicine Humans Aged 0303 health sciences Kidney [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology 030306 microbiology business.industry Medical record Immunosuppression Organ Transplantation Middle Aged medicine.disease Kidney Transplantation Transplant Recipients 3. Good health Infectious Diseases medicine.anatomical_structure Parasitic disease Cohort Female France Pancreas Transplantation medicine.symptom Pancreas business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Immunosuppressive Agents |
| Zdroj: | Médecine et Maladies Infectieuses Médecine et Maladies Infectieuses, Elsevier Masson, 2019, ⟨10.1016/j.medmal.2019.07.010⟩ |
| ISSN: | 1769-6690 0399-077X |
| DOI: | 10.1016/j.medmal.2019.07.010⟩ |
| Popis: | International audience; Introduction. – Gastrointestinal disorders in solid organ recipients may have various origins including cryptosporidiosis and microsporidiosis. The prevalence of these infections is poorly known in solid organ transplant (SOT) patients in industrialized countries. Methods. – We prospectively assessed the infectious causes of diarrhea in SOT patients. Secondary objectives were to gain further insight into the main characteristics of cryptosporidiosis, and to assess risk factors for this infection. All adult kidney and/or pancreas recipients presenting with diarrhea and admitted to our facility between May1, 2014 and June 30, 2015 were enrolled. As tool sample was analyzed using a standardized protocol including bacteriological, virological, and parasitological investigations. Data related to clinical symptoms, immunosuppression, and environmental potential risk factors were collected through a self-administered questionnaire and computerized medical records. Results. – Out of 73 enrolled patients, 36had infectious diarrhea (49.3%). Viruses ranked first(17/36),followed by parasites and fungi (11/17). Cryptosporidiosis was the most common parasitic disease (n=6 patients). We observed four microsporidiosis cases. The estimated prevalence of cryptosporidiosis and microsporidiosis in this cohort was 3.7 and 2.40/00, respectively. No significant risk factor for cryptosporidiosis or microsporidiosis, neither environmental nor immunological, could be evidenced. Conclusion. – Both cryptosporidiosis and microsporidiosis represent a significant cause of diarrhea in kidney transplant recipients. |
| Databáze: | OpenAIRE |
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