The association between personality, pain threshold and a single nucleotide polymorphism (rs3813034) in the 3′-untranslated region of the serotonin transporter gene (SLC6A4)
| Autor: | Ohoshi Murayama, Yasukazu Ogai, Jun Aoki, Kazutaka Ikeda, Eiji Yoshihara, Kazuhiko Iwahashi |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pain Threshold Untranslated region medicine.medical_specialty Genotype Single-nucleotide polymorphism Personality Assessment Polymorphism Single Nucleotide Asian People Gene Frequency Untranslated Regions Physiology (medical) Internal medicine Threshold of pain medicine Humans Allele Alleles Serotonin transporter Pain Measurement Serotonin Plasma Membrane Transport Proteins Genetics Analysis of Variance biology business.industry Patient Selection Novelty seeking General Medicine Middle Aged Cold Temperature Endocrinology Neurology biology.protein Female Surgery Temperament and Character Inventory Neurology (clinical) Gene polymorphism business Personality |
| Zdroj: | Journal of Clinical Neuroscience. 17:574-578 |
| ISSN: | 0967-5868 |
| DOI: | 10.1016/j.jocn.2009.08.020 |
| Popis: | In 181 healthy Japanese volunteers we examined the relationship between personality, sensitivity to pain and a single nucleotide polymorphism (rs3813034) in the 3′ untranslated region (3′ UTR) of the serotonin transporter (5-HTT) gene (SLC6A4). Pain sensitivity was assessed by using cold and pressure thresholds. Personality was assessed by the Temperament and Character Inventory (TCI). Males without the T allele (G/G) showed a significantly higher spiritual acceptance (ST3) score than those who had the T allele (T/T and T/G). Females with the T allele (T/T and T/G) showed significantly higher transpersonal identification (ST2) and self-transcendence (ST) scores than those without the T allele (G/G). As for pain sensitivity and its relationship with TCI, we found a low negative correlation between cold water stimulation, disorderliness (NS4) and novelty seeking (NS) in males, whereas in females we found a low positive correlation between cold water stimulation, self-acceptance (SD4) and pure-hearted principles (C5), as well as pressure stimulation and SD4. It is possible that the 5-HTT 3′ UTR gene polymorphism affects the character dimensions of Cloniger’s theory, and that there might be a low correlation between pain and a part of the personality. |
| Databáze: | OpenAIRE |
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