A mAb for the detection of the antiretroviral drug emtricitabine

Autor: Ae S. Youngpairoj, Thomas H. Vanderford, Matthew S. Reed, Timothy C. Granade, Chou-Pong Pau, Jan Pohl, William M. Switzer, Walid Heneine
Rok vydání: 2022
Předmět:
Zdroj: AIDS (London, England). 36(13)
ISSN: 1473-5571
Popis: Antibody-based testing for emtricitabine (FTC), a critical component of pre-exposure prophylaxis and antiretroviral therapy, would provide low-cost detection for clinical monitoring to improve adherence. We developed a mAb (5D2) to FTC and demonstrated its high specificity and physiologically relevant linear range of detection in a competitive enzyme immunoassay. Thus, this mAb is a key reagent that will enable simple and low-cost lateral flow assays and enzyme immunoassays for adherence monitoring.
Databáze: OpenAIRE