A well‐tolerated core needle muscle biopsy process suitable for children and adults
Autor: | Emilie D. Douine, Florian Barthélémy, Shirley Nieves-Rodriguez, M. Carrie Miceli, Jeremy D. Woods, Jonathan Wanagat, Stanley F. Nelson, Richard T. Wang |
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Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Physiology Duchenne muscular dystrophy Conscious Sedation Pain Procedural 030105 genetics & heredity 0302 clinical medicine Sampling (medicine) Anesthetics Local Child Ultrasonography Clinical Research Article medicine.diagnostic_test Middle Aged medicine.anatomical_structure Child Preschool Female Tissue Preservation Radiology muscle biopsy Adult Image-Guided Biopsy Muscle tissue medicine.medical_specialty Adolescent Vacuum Specimen Handling Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience Physiology (medical) Biopsy medicine Humans skeletal muscle Muscle Skeletal Adverse effect Clinical Research Articles Aged clinical trials Muscle biopsy business.industry Reproducibility of Results Skeletal muscle needle biopsy medicine.disease Muscular Dystrophy Duchenne Clinical trial Case-Control Studies Biopsy Large-Core Needle Neurology (clinical) business 030217 neurology & neurosurgery |
Zdroj: | Muscle & Nerve |
ISSN: | 1097-4598 0148-639X |
Popis: | Introduction Serial muscle biopsies within clinical trials for Duchenne muscular dystrophy (DMD) are critical to document therapeutic responses. Less invasive means of sampling muscle are needed. Methods We analyzed a retrospective consecutive case-series cohort of vacuum-assisted core needle muscle biopsy procedures performed on healthy and dystrophic individuals at a single institution assessing for safety and reliability of obtaining sufficient high quality biopsy tissue for histologic assessment in adult and pediatric subjects. Results Of 471 muscle cores from 128 biopsy procedures, 377-550mg of total muscle tissue was obtained per procedure with mean core weight of 129mg (SD 25.1mg). All Biopsies were adequate for histological assessment. There were no significant adverse events. Discussion This core needle biopsy approach, when combined with improved sample processing, provides a safe means to consistently obtain muscle samples for diagnostic and clinical trial applications. This article is protected by copyright. All rights reserved. |
Databáze: | OpenAIRE |
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