A well‐tolerated core needle muscle biopsy process suitable for children and adults

Autor: Emilie D. Douine, Florian Barthélémy, Shirley Nieves-Rodriguez, M. Carrie Miceli, Jeremy D. Woods, Jonathan Wanagat, Stanley F. Nelson, Richard T. Wang
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Physiology
Duchenne muscular dystrophy
Conscious Sedation
Pain
Procedural
030105 genetics & heredity
0302 clinical medicine
Sampling (medicine)
Anesthetics
Local
Child
Ultrasonography
Clinical Research Article
medicine.diagnostic_test
Middle Aged
medicine.anatomical_structure
Child
Preschool
Female
Tissue Preservation
Radiology
muscle biopsy
Adult
Image-Guided Biopsy
Muscle tissue
medicine.medical_specialty
Adolescent
Vacuum
Specimen Handling
Young Adult
03 medical and health sciences
Cellular and Molecular Neuroscience
Physiology (medical)
Biopsy
medicine
Humans
skeletal muscle
Muscle
Skeletal
Adverse effect
Clinical Research Articles
Aged
clinical trials
Muscle biopsy
business.industry
Reproducibility of Results
Skeletal muscle
needle biopsy
medicine.disease
Muscular Dystrophy
Duchenne
Clinical trial
Case-Control Studies
Biopsy
Large-Core Needle
Neurology (clinical)
business
030217 neurology & neurosurgery
Zdroj: Muscle & Nerve
ISSN: 1097-4598
0148-639X
Popis: Introduction Serial muscle biopsies within clinical trials for Duchenne muscular dystrophy (DMD) are critical to document therapeutic responses. Less invasive means of sampling muscle are needed. Methods We analyzed a retrospective consecutive case-series cohort of vacuum-assisted core needle muscle biopsy procedures performed on healthy and dystrophic individuals at a single institution assessing for safety and reliability of obtaining sufficient high quality biopsy tissue for histologic assessment in adult and pediatric subjects. Results Of 471 muscle cores from 128 biopsy procedures, 377-550mg of total muscle tissue was obtained per procedure with mean core weight of 129mg (SD 25.1mg). All Biopsies were adequate for histological assessment. There were no significant adverse events. Discussion This core needle biopsy approach, when combined with improved sample processing, provides a safe means to consistently obtain muscle samples for diagnostic and clinical trial applications. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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