Discovery of novel drugs for Chagas disease: is carbonic anhydrase a target for antiprotozoal drugs?

Autor:	Alane Beatriz Vermelho, Giseli Capaci Rodrigues, Alessio Nocentini, Felipe R. P. Mansoldo, Claudiu T. Supuran
Rok vydání:	2022
Předmět:	Trypanosoma cruzi Drug Discovery Antiprotozoal Agents Animals Chagas Disease Carbonic Anhydrase Inhibitors Trypanocidal Agents Carbonic Anhydrases
Zdroj:	Expert Opinion on Drug Discovery. 17:1147-1158
ISSN:	1746-045X 1746-0441
DOI:	10.1080/17460441.2022.2117295
Popis:	Carbonic anhydrase (CA) arose significant interest as a potential new target for Chagas disease since its discovery inWe discuss the positive and negative aspects ofThe search for new targets and drugs is a significant challenge worldwide, and TcCA is a potential candidate for developing new drugs. Several studied inhibitors were active against
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baad34146ea66694d7011c5924df7a7e https://doi.org/10.1080/17460441.2022.2117295 Zobrazit plný text záznamu