High fructose-enriched diet synergistically exacerbates endocrine but not metabolic changes in letrozole-induced polycystic ovarian syndrome in Wistar rats
| Autor: | A.O. Ojewale, Adesola A. Oniyide, Olorunsola I. Adeyomoye, Adedeji B. Kayode, Isaac O. Ajadi, Kehinde S. Olaniyi, Olabimpe C. Badejogbin, Christopher O. Akintayo, Anjola D. Johnson |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Infertility medicine.medical_specialty endocrine system diseases Uterus Ovary Fructose 03 medical and health sciences Follicle-stimulating hormone 0302 clinical medicine Internal medicine PCOS medicine Endocrine system lcsh:Social sciences (General) lcsh:Science (General) Testosterone Multidisciplinary business.industry medicine.disease female genital diseases and pregnancy complications Metabolism 030104 developmental biology medicine.anatomical_structure Endocrinology lcsh:H1-99 Endocrine business 030217 neurology & neurosurgery lcsh:Q1-390 Research Article Hormone Fallopian tube |
| Zdroj: | Heliyon Heliyon, Vol 7, Iss 1, Pp e05890-(2021) |
| ISSN: | 2405-8440 |
| DOI: | 10.1016/j.heliyon.2020.e05890 |
| Popis: | Background Polycystic Ovarian Syndrome (PCOS) is a multifactorial endocrine-metabolic disorder that highly contributes to the prevalence of infertility globally. The increased consumption of refined carbohydrate, particularly fructose has been associated with pandemic metabolic disorders, including in women of reproductive age. However, the effects of high fructose consumption (FRD) on endocrine and metabolic disorders associated with PCOS are not clear. Therefore, this study investigated the effects of FRD on endocrine/metabolic changes in letrozole-induced PCOS in Wistar rats. Materials and methods Twenty-eight adult female Wistar rats were randomly allotted into 4 groups and treated with vehicle, letrozole (LET; 0.5 mg/kg), FRD (D-fructose chow pellet mixture) and LET + FRD. The treatment lasted for 21days. Results Data showed a significant increase in ovarian weight, liver weight, luteinising hormone (LH), testosterone and decrease in follicle stimulating hormone as well as moderate histopathological changes in the fallopian tube, uterus and liver of animals with PCOS. FRD-treated group showed a significant increase in ovarian weight and liver weight but no significant alteration in hormonal profile or histopathological changes in uterus and fallopian tube. However, FRD significantly altered hormonal profile with consequent histopathological changes in fallopian tube and uterus but FRD did not alter ovarian/liver weight or blood glucose in animals with PCOS when compared with animals without PCOS. Conclusion The present results demonstrate that FRD synergistically aggravates endocrine but not metabolic changes in PCOS, suggesting that FRD might deteriorate endocrine-related phenotypes in PCOS. Fructose; Endocrine; Infertility; Metabolism; Ovary; PCOS |
| Databáze: | OpenAIRE |
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