Persistent adenoviral infection and chronic airway obstruction in children
| Autor: | J Marin, S Kopriva, V Macek, J Sorli |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adolescent medicine.drug_class Fluorescent Antibody Technique Peak Expiratory Flow Rate Critical Care and Intensive Care Medicine Adenovirus Infections Human Capsid Bronchodilator medicine Bronchiolitis Viral Humans Child Antigens Viral Lung medicine.diagnostic_test business.industry Adenoviruses Human Respiratory disease Infant medicine.disease Asthma Bronchoalveolar lavage medicine.anatomical_structure Bronchiolitis Child Preschool Chronic Disease Immunology Etiology Corticosteroid Viral disease business Bronchoalveolar Lavage Fluid |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 150:7-10 |
| ISSN: | 1535-4970 1073-449X |
| Popis: | Previous studies from several laboratories have established that adenovirus is a common cause of severe childhood bronchiolitis. The observation that children with an established history of bronchiolitis subsequently developed unremitting airways obstruction even after adequate steroid therapy led us to postulate that this bronchial obstruction might be due to persistence of an adenoviral infection. This hypothesis was tested by performing bronchoalveolar lavage (BAL) on a group of 34 children with a mean age of 5 yr (range, 14 mo to 14 yr) who showed an unfavorable response to standard corticosteroid and bronchodilator therapy. Analysis of cytospin preparations of BAL fluid at the light-microscopic level, using a monoclonal antibody to detect adenoviral antigens, demonstrated that capsid protein was present in 31 of 34 (94%) of the children examined. Limited repeat studies within 1 yr showed 6 of 8 (75%) were positive twice when tested on two occasions, and that three were positive in all occasions when sampled three times. Cultures of the BAL fluid were also positive for adenovirus in six of six cultures performed, indicating that the virus was in some cases replicating. Similar studies of control patients without persistent asthma showed no evidence of adenovirus. We conclude that persistent and/or latent adenoviral infection may contribute to the pathogenesis of childhood asthma in which there is an unfavorable response to steroid and bronchodilatation therapy. |
| Databáze: | OpenAIRE |
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