The emergence of an unassigned complex recombinant form in a Pakistani HIV-infected individual
| Autor: | Faisal Sultan, Syed Faisal Mahmood, Ayesha Iftikhar, Dilsha Zahid, Syed Hani Abidi, Sadaf Naeem, Uroosa Tariq, Syed Ali |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Anti-HIV Agents Population HIV Infections Drug resistance Biology Genetic analysis Virus law.invention 03 medical and health sciences Medical microbiology law Virology Drug Resistance Viral medicine Humans Pakistan education Phylogeny 030304 developmental biology Recombination Genetic 0303 health sciences education.field_of_study 030306 microbiology Outbreak General Medicine HIV-1 Recombinant DNA |
| Zdroj: | Archives of Virology. 165:967-972 |
| ISSN: | 1432-8798 0304-8608 |
| Popis: | In Pakistan, the HIV situation has gone from an outbreak to a concentrated epidemic, and the virus has now crossed into the low-risk population. In addition, several new HIV outbreaks have occurred in different parts of the country. HIV-1 subtype A has been the major epidemic subtype in Pakistan; however, as the epidemic has grown, the emergence of several new subtypes and recombinant forms has been observed. Here, we present the first case and genetic analysis of an unassigned, complex recombinant form in a Pakistani HIV-infected individual with virological failure. Genetic analysis of the sequence indicated that this recombinant form is multi-drug resistant, harboring drug resistance mutations against more than one class of antiretroviral drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink