The Levels of Interferon-gamma Release as a Biomarker for Non-small-cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors

Autor:	Norio Okamoto, Yumiko Samejima, Shingo Nasu, Yoshimi Noda, Shoji Hashimoto, Ayako Tanaka, Hiromi Kawasumi, Hiroko Yoshida, Hidekazu Suzuki, Yoshitaka Tamura, Toshio Tanaka, Kunimitsu Kawahara, Tomohiro Kanai, Naoko Morishita, Tomonori Hirashima, Akane Matsushita
Rok vydání:	2019
Předmět:	Adult Male Cancer Research medicine.medical_specialty Lung Neoplasms Time Factors T-Lymphocytes medicine.medical_treatment Interferon gamma release assay Antibodies Monoclonal Humanized Gastroenterology B7-H1 Antigen Interferon-gamma 03 medical and health sciences Antineoplastic Agents Immunological 0302 clinical medicine Latent Tuberculosis Carcinoma Non-Small-Cell Lung Internal medicine Biomarkers Tumor medicine Humans Interferon gamma Prospective Studies Prospective cohort study Lung cancer Aged Aged 80 and over Latent tuberculosis business.industry Antibodies Monoclonal General Medicine Immunotherapy Middle Aged medicine.disease Nivolumab Oncology 030220 oncology & carcinogenesis Disease Progression Biomarker (medicine) Female Lung Diseases Interstitial business medicine.drug
Zdroj:	Anticancer Research. 39:6231-6240
ISSN:	1791-7530 0250-7005
Popis:	BACKGROUND/AIM The present study aimed to prospectively examine the usefulness of interferon-gamma (IFN-γ) release (IGR) as a biomarker in non-small-cell lung cancer patients receiving immune checkpoint inhibitor treatment (ICI-Tx). PATIENTS AND METHODS IGR was measured using enzyme-linked immunosorbent assay at four time points: within 14 days before ICI-Tx (T1), and 8±3 (T2), 22±7 (T3), and 43±7 (T4) days after ICI-Tx. RESULTS Twenty-nine patients were divided into three groups based on IFN-γ levels in the IGR-positive control: Group-1 (n=8) with
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa50621bdf16b95385b94d4bb25fb65 https://doi.org/10.21873/anticanres.13832 Zobrazit plný text záznamu