Adult neuronal regeneration in the telencephalon of the killifish Aphaniops hormuzensis
| Autor: | Mina Motamedi, Azad Teimori, Amir Reza Soltani |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Telencephalon
0106 biological sciences 0301 basic medicine Aging Pathology medicine.medical_specialty Central nervous system H&E stain Biology 010603 evolutionary biology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Genetics medicine Animals Regeneration Ecology Evolution Behavior and Systematics Cell Proliferation Neurons Cerebrum Killifishes Regeneration (biology) Nervous tissue Immunohistochemistry 030104 developmental biology medicine.anatomical_structure Vacuolization chemistry Gliosis Molecular Medicine Animal Science and Zoology medicine.symptom Bromodeoxyuridine Developmental Biology |
| Zdroj: | Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 334:350-361 |
| ISSN: | 1552-5015 1552-5007 |
| DOI: | 10.1002/jez.b.23008 |
| Popis: | The potential of central nervous system regeneration was evaluated for the first time in the injured brain of the old world killifish Aphaniops hormuzensis. The histomorphological organization in the regeneration procedure was evaluated using the hematoxylin and eosin (H&E) staining and the bromodeoxyuridine (BrdU) immunohistochemistry technique. The histological tissue sections were sampled daily for 10 days. Based on the H&E staining, a large gliosis reaction was detected along with vacuolization and telencephalon deformation on 1-day post-lesion (dpl). The vacuolated zone declined fast and the telencephalon hemisphere recovered on 3 dpl. The symptoms of injured telencephalon nervous tissue were resolved within 7 dpl in both genders. In the BrdU test of the control group, BrdU-labeled cells were observed in the ventricular zone (VZ), pallium (Pa), and lateral pallium (LPa). On 1 dpl, the BrdU+ cells accumulated in the VZ, Pa, and LPa (located near the injury area). From 3 dpl onwards, the BrdU+ cells were reduced in the telencephalic VZ, Pa, and LPa. Based on the BrdU+ results, the adult brain in A. hormuzensis possesses a remarkable capacity for neuronal regeneration. By taking into account the high neural regeneration potency of A. hormuzensis and its relatively short lifespan, it could be concluded that besides the currently known models, the members of aphaniid fishes could probably be valuable animals to study the regeneration phenomenon in the vertebrates. |
| Databáze: | OpenAIRE |
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