A new Case of Hb Little Rock [β143(H21)His → Gln], a high affinity variant. Study during pregnancy
| Autor: | C. Lacombe, Frédéric Galactéros, Alain Francina, Faouzi Baklouti, Jacques Delaunay, G. Souillet, E. Dorléac, Nicole Arous, R. C. Rudigoz, Jean-Philippe Rosa |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
medicine.medical_specialty P50 Hemoglobins Abnormal Clinical Biochemistry chemistry.chemical_element Peptide Cooperativity Biology Oxygen High-performance liquid chromatography Pregnancy Internal medicine medicine Humans Amino Acids Chromatography High Pressure Liquid Genetics (clinical) chemistry.chemical_classification Fetus Biochemistry (medical) Hematology medicine.disease Endocrinology chemistry Gestation Female |
| Zdroj: | Hemoglobin. 11:113-122 |
| ISSN: | 1532-432X 0363-0269 |
| DOI: | 10.3109/03630268709005784 |
| Popis: | A new case of Hb Little Rock [beta 143(H21)His----Gln] is described. This high affinity variant (P50 = 15 mm Hg in whole cells) has a nearly normal cooperativity. The abnormal beta chain is readily detectable using urea-Triton X-100 electrophoresis. The altered beta T-14 peptide was separated by high performance liquid chromatography. The proposita was followed during a pregnancy. Oxygen unloading was reduced, but normal oxygen loading was maintained in the fetus. There were neither placental abnormalities, nor intrauterine growth retardation. |
| Databáze: | OpenAIRE |
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