Fever, confusion, acute kidney injury: is this atypical neuroleptic malignant syndrome following polypharmacy with clozapine and risperidone?
| Autor: | Scott Cherry, Daniel Wysoczanski, Dan Siskind, Priyangika Halangoda, Valeria Spivak |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Fever medicine.medical_treatment Atypical neuroleptic 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Neuroleptic Malignant Syndrome Confusion Antipsychotic Psychiatry Clozapine Aged Polypharmacy Risperidone business.industry Acute kidney injury Acute Kidney Injury medicine.disease Malignant syndrome 030227 psychiatry Neuroleptic malignant syndrome Psychiatry and Mental health Schizophrenia business 030217 neurology & neurosurgery Antipsychotic Agents medicine.drug |
| Zdroj: | Australasian Psychiatry. 24:602-603 |
| ISSN: | 1440-1665 1039-8562 |
| DOI: | 10.1177/1039856216649768 |
| Popis: | Objective: Clozapine is the gold-standard antipsychotic medication for treatment-refractory schizophrenia (TRS). However, one potentially lethal side effect of clozapine, as with other antipsychotics, is neuroleptic malignant syndrome (NMS) which could present differently in clozapine therapy. ‘Atypical NMS’ is a recognised variant of NMS with less rigidity and delayed elevation of creatine kinase; this variant is associated with clozapine. Method: A case from the author’s clinical practice was reviewed. Results: A 67-year-old man with TRS was treated with clozapine. Unfortunately, his physical condition deteriorated and he presented with atypical NMS, which initially was treated as presumable urinary tract infection. Conclusions: Atypical NMS is associated with clozapine. This case exposes the potential difficulties in diagnosis, and highlights the importance of considering less common diagnoses in acutely unwell psychiatric patients. |
| Databáze: | OpenAIRE |
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