Circulating inflammation-related factors are correlated with systemic redox status in IgA nephropathy; a case-control study
| Autor: | Jessica Furriol, Hans-Peter Marti, Grete Jonsson, Terje Apeland, Anastasia Ushakova, Kari W. Stangeland, Mohammad Azam Mansoor |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Parathyroid hormone Renal function Inflammation medicine.disease_cause Biochemistry Nephropathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physiology (medical) Internal medicine medicine Humans Osteopontin Creatinine biology business.industry Case-control study Glomerulonephritis IGA medicine.disease 030104 developmental biology Endocrinology chemistry Case-Control Studies biology.protein medicine.symptom business Oxidation-Reduction 030217 neurology & neurosurgery Oxidative stress Biomarkers Glomerular Filtration Rate |
| Zdroj: | Free radical biologymedicine. 155 |
| ISSN: | 1873-4596 |
| Popis: | Background IgA nephropathy (IGAN) is characterized by oxidative stress and inflammation. In the present study, we explored the relationship of redox status vs. that of circulating inflammation-related factors with other biomarkers in patients with IGAN. Methods This is a case-control study comparing patients with IGAN (Stage 1–4) to healthy controls. Forty patients and 40 controls were matched for age and sex. Two circulating dynamic redox parameters were analysed: oxidized free cysteine (Cys) and nitrate. Thirty-seven inflammation-related factors were measured in serum. Results The patients had elevated levels of oxidized free Cys and nitrate, indicating the presence of oxidative stress. Nine circulating inflammation-related factors were higher in the serum of patients than in that of controls. The most important factors were APRIL, MMP-3, osteopontin, TNFR1 and TWEAK. Inflammation-related factors were positively correlated with oxidized free Cys, nitrate, creatinine and parathyroid hormone (PTH) in the patients. The correlation coefficients of Latent Inflammatory Factor vs. oxidized free Cys and nitrate were r = 0.43 (p = 0.007) and r = 0.51 (p = 0.001), respectively. This finding persisted after adjusting for the glomerular filtration rate. Conclusions Patients with IGAN had disturbed redox status. Several circulating inflammation-related factors were elevated, suggesting activation of the non-canonical NF-kB pathway. There was a positive relationship between systemic redox status and the level of inflammation-related factors, partially independent of GFR. The present findings raise the question of whether circulating oxidized free Cys and/or nitrate may be employed as prognostic biomarkers for IGAN in the future. |
| Databáze: | OpenAIRE |
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