Circulation of HRSV in Belgium
| Autor: | Eva Reijmen, Philippe Lemey, A. Vankeerberghen, Marc Van Ranst, Lieselot Houspie, Freya Vaeyens, Valentijn Vergote, Els Keyaerts, Hans De Beenhouwer |
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| Přispěvatelé: | Laboratory of Molecullar and Cellular Therapy, Basic (bio-) Medical Sciences, Faculty of Medicine and Pharmacy, Clinical sciences, Medical Genetics, Department of Bio-engineering Sciences, Leung, Frederick CC |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Internationality
Time Factors Epidemiology medicine.disease_cause phylogeny Belgium Genotype Clinical Epidemiology Pediatric Epidemiology Child chemistry.chemical_classification Genetics Molecular Epidemiology education.field_of_study Mutation Multidisciplinary Phylogenetic tree Respiratory Syncytial Virus Human/genetics Middle Aged Amino acid Genetic Epidemiology Medicine young adult Seasons Research Article Adult Adolescent Child preschool Clinical Research Design Science Population Respiratory Syncytial Virus Infections Biology Microbiology Infectious Disease Epidemiology Evolution Molecular Age Distribution Phylogenetics Virology Genetic variation medicine Humans Selection Genetic education Epidemics Belgium/epidemiology Aged Population Biology Genetic Variation Infant Respiratory Syncytial Virus Infections/epidemiology Hypervariable region Viral Disease Diagnosis species specificity chemistry Respiratory Syncytial Virus Human mutation |
| Zdroj: | PLoS ONE, Vol 8, Iss 4, p e60416 (2013) PLoS ONE |
| Popis: | Molecular surveillance of HRSV in Belgium for 15 consecutive seasons (1996-2011) revealed a shift from a regular 3-yearly cyclic pattern, into a yearly alternating periodicity where HRSV-B is replaced by HRSV-A. Phylogenetic analysis for HRSV-A demonstrated the stable circulation of GA2 and GA5, with GA2 being dominant over GA5 during 5 consecutive seasons (2006-2011). We also identified 2 new genotype specific amino acid mutations of the GA2 genotype (A122 and Q156) and 7 new GA5 genotype specific amino acid mutations (F102, I108, T111, I125, D161, S191 and L217). Several amino acid positions, all located in the second hypervariable region of HRSV-A were found to be under positive selection. Phylogenetic analysis of HRSV-B showed the circulation of GB12 and GB13, where GB13 represented 100% of the isolated strains in 4 out of 5 consecutive seasons (2007-2011). Amino acids under positive selection were all located in the aminoterminal hypervariable region of HRSV-B, except one amino acid located in the conserved region. The genotype distribution within the HRSV-B subgroup has evolved from a co-circulation of multiple genotypes to the circulation of a single predominant genotype. The Belgian GB13 strains circulating since 2006, all clustered under the BAIV branch and contained several branch specific amino acid substitutions. The demographic history of genotypes GA2, GA5 and GB13 demonstrated a decrease in the total GA2 and GA5 population size, coinciding with the global expansion of the GB13 population. The emergence of the GB13 genotype resulted in a newly established balance between the predominant genotypes. ispartof: PLoS One vol:8 issue:4 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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