25 Hz electromagnetic field exposure has no effect on cell cycle distribution and apoptosis in U-937 and HCA-2/1cch cells
| Autor: | M. J. Ruiz Gómez, L. de la Peña, L. Gil, M. Martínez Morillo, J.M. Pastor |
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| Rok vydání: | 2001 |
| Předmět: |
Time Factors
Biophysics Apoptosis Biology Dexamethasone Flow cytometry Electromagnetic Fields Tumor Cells Cultured Electrochemistry medicine Humans Physical and Theoretical Chemistry medicine.diagnostic_test Cell growth Cell Cycle U937 Cells General Medicine Cell cycle medicine.disease In vitro Cell biology Cell culture Adenocarcinoma Cell Division medicine.drug |
| Zdroj: | Bioelectrochemistry. 53:137-140 |
| ISSN: | 1567-5394 |
| DOI: | 10.1016/s0302-4598(00)00119-7 |
| Popis: | It is reported that exposure to 50 Hz extremely low-frequency electromagnetic field (ELF-EMF) can produce apoptosis and small variations in cell cycle distribution on different cell lines. In order to study the effect of ELF-EMF on tumoral cells in vitro, two cell lines (U-937, from a histiocytic lymphoma, and HCA-2/1cch, from a human colon adenocarcinoma) were exposed to 25 Hz, 1.5 mT, for 2 h and 45 min. Cell cycle distribution, apoptosis (spontaneous and dexamethasone-induced) and cell growth were evaluated. Neither significant alteration in cell cycle phases nor induction of apoptosis was observed. Nevertheless, the relative cell number was found to decrease to 55.84±7.35% (p |
| Databáze: | OpenAIRE |
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