Serotonin activates angiogenic phosphorylation signaling in human endothelial cells
| Autor: | Ali Zamani, Zhican Qu |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Blood Platelets
Vascular Endothelial Growth Factor A Serotonin medicine.medical_specialty Angiogenesis Biophysics Neovascularization Physiologic Angiogenesis Inhibitors Biology Models Biological Biochemistry Cell Line Kinase phosphorylation chemistry.chemical_compound Structural Biology Neoplasms Internal medicine Genetics medicine Humans Phosphorylation Receptor Neurotransmitter Molecular Biology Protein kinase B PI3K/AKT/mTOR pathway Clinical Trials as Topic Neovascularization Pathologic Endothelial Cells Cell Biology Cell biology Endocrinology chemistry Endothelium Vascular Signal transduction Signal Transduction |
| Zdroj: | FEBS Letters. 586:2360-2365 |
| ISSN: | 0014-5793 |
| Popis: | Serotonin, a known neurotransmitter, also functions as an angiokine to promote angiogenesis. The majority of serotonin in the human body is stored in platelets, and platelet aggregation leads to significant release of serotonin in thrombotic tumor environment. We have investigated serotonin signaling in human endothelial cells. Through G-protein-coupled receptors, serotonin at physiologically relevant concentrations activated Src/PI3K/AKT/mTOR/p70S6K phosphorylation signaling, and this activation was similar to that seen with VEGF. This finding provides insight into the overlapping angiogenic signaling pathways stimulated by serotonin in tumor environment, and suggests one of the mechanisms underlying resistance to current VEGF-targeting antiangiogenic therapy against cancer. |
| Databáze: | OpenAIRE |
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