Generation of shape complexity through tissue conflict resolution
Autor: | Alexandra B. Rebocho, J. Andrew Bangham, J. Richard Kennaway, Enrico Coen, Paul Southam |
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Rok vydání: | 2016 |
Předmět: |
0106 biological sciences
0301 basic medicine Polarity (physics) QH301-705.5 Science Morphogenesis Flowers Biology 01 natural sciences General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Conflict resolution Botany Antirrhinum PIN1 polarity Biology (General) General Immunology and Microbiology Mechanism (biology) General Neuroscience food and beverages Gene Expression Regulation Developmental General Medicine Animal development 3d shapes tissue conflict resolution orthognal cell files Antirrhinum majus 030104 developmental biology out-of-plane deformations Medicine Biological system Developmental biology Differential growth 010606 plant biology & botany |
Zdroj: | eLife, Vol 6 (2017) |
ISSN: | 2050-084X |
Popis: | Out-of-plane tissue deformations are key morphogenetic events during plant and animal development that generate 3D shapes, such as flowers or limbs. However, the mechanisms by which spatiotemporal patterns of gene expression modify cellular behaviours to generate such deformations remain to be established. We use the Snapdragon flower as a model system to address this problem. Combining cellular analysis with tissue-level modelling, we show that an orthogonal pattern of growth orientations plays a key role in generating out-of-plane deformations. This growth pattern is most likely oriented by a polarity field, highlighted by PIN1 protein localisation, and is modulated by dorsoventral gene activity. The orthogonal growth pattern interacts with other patterns of differential growth to create tissue conflicts that shape the flower. Similar shape changes can be generated by contraction as well as growth, suggesting tissue conflict resolution provides a flexible morphogenetic mechanism for generating shape diversity in plants and animals. |
Databáze: | OpenAIRE |
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