MicroRNAs Both Promote and Antagonize Longevity in C. elegans
| Autor: | Katherine Zhou, Zachary Pincus, Alexandre de Lencastre, Siu Sylvia Lee, Frank J. Slack, Masaomi Kato |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Aging
media_common.quotation_subject Longevity Molecular Sequence Data Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Stress Physiological Gene expression microRNA Animals Humans Insulin-Like Growth Factor I Caenorhabditis elegans Gene 030304 developmental biology media_common Genetics 0303 health sciences Base Sequence Agricultural and Biological Sciences(all) biology Sequence Analysis RNA Biochemistry Genetics and Molecular Biology(all) G2-M DNA damage checkpoint biology.organism_classification MicroRNAs Nucleic Acid Conformation Signal transduction General Agricultural and Biological Sciences Sequence Alignment 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Current Biology. 20:2159-2168 |
| ISSN: | 0960-9822 |
| Popis: | Summary Background Aging is under genetic control in C. elegans , but the mechanisms of life-span regulation are not completely known. MicroRNAs (miRNAs) regulate various aspects of development and metabolism, and one miRNA has been previously implicated in life span. Results Here we show that multiple miRNAs change expression in C. elegans aging, including novel miRNAs, and that mutations in several of the most upregulated miRNAs lead to life-span defects. Some act to promote normal life span and stress resistance, whereas others inhibit these phenomena. We find that these miRNAs genetically interact with genes in the DNA damage checkpoint response pathway and in the insulin signaling pathway. Conclusions Our findings reveal that miRNAs both positively and negatively influence life span. Because several miRNAs upregulated during aging regulate genes in conserved pathways of aging and thereby influence life span in C. elegans , we propose that miRNAs may play important roles in stress response and aging of more complex organisms. |
| Databáze: | OpenAIRE |
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