Periodontal disease severity and urinary albumin excretion in middle-aged hypertensive patients
| Autor: | Dimitris Tousoulis, Ioannis Kallikazaros, Ioannis Andrikou, Costas Tsioufis, Costas Thomopoulos, Athanasios Kordalis, Alexandros Kasiakogias, Georgios Giamarelos, Kostas Toutouzas, Christodoulos Stefanadis, Nikos Soldatos |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Periodontal examination Urinary system Hemodynamics Gastroenterology Severity of Illness Index Excretion Internal medicine Medicine Albuminuria Humans Periodontal Diseases Proteinuria business.industry Albumin Middle Aged Blood pressure Endocrinology C-Reactive Protein Cross-Sectional Studies Circulatory system Hypertension Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | The American journal of cardiology. 107(1) |
| ISSN: | 1879-1913 |
| Popis: | To address whether periodontal disease indexes are associated with urinary albumin-to-creatinine ratio (UACR) in conditions of high and low systemic inflammation as reflected by levels of high-sensitivity C-reactive protein (hs-CRP) in untreated hypertensive patients, we studied 242 hypertensive patients 51 ± 9 years old (24-hour systolic/diastolic blood pressure [BP] 132 ± 10/83 ± 8 mm Hg) with varying severity of periodontal disease evaluated by 3 periodontal disease indexes (PDIs) (i.e., mean clinical loss of attachment, maximum probe depth, and gingival bleeding index). Patients underwent BP measurements, echocardiography, and periodontal examination, and from fasting blood samples we assessed metabolic profile and hs-CRP. From 2 nonconsecutive overnight spot urine samples we evaluated UACR. With respect to median hs-CRP and UACR levels (1.67 mg/L and 10 mg/g, respectively), the total population was divided into patients with low-UACR/low–hs-CRP (n = 65), low-UACR/high–hs-CRP (n = 63), high-UACR/low–hs-CRP (n = 51), and high-UACR/high–hs-CRP (n = 63). PDIs differed among the 4 groups, and those with high UACR had significantly higher 24-hour systolic BP compared to those with low UACR. UACR was determined by all periodontal disease indexes, hs-CRP, and the interaction of each periodontal disease index with hs-CRP. In addition, mean clinical loss of attachment was the strongest determinant of the high-UACR/high–hs-CRP pattern among all studied periodontal disease indexes. In conclusion, in untreated middle-aged hypertensive patients, periodontal disease indexes and hs-CRP have a synergistic effect on UACR levels independently of the underlying hemodynamic load. |
| Databáze: | OpenAIRE |
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