Hydroxyapatite nanoparticles drive the potency of Toll-like receptor 9 agonist for amplified innate and adaptive immune response

Autor: Qin, Zeng, Ruiqi, Wang, Yuchen, Hua, Hongfeng, Wu, Xuening, Chen, You-Cai, Xiao, Qiang, Ao, Xiangdong, Zhu, Xingdong, Zhang
Rok vydání: 2022
Předmět:
Zdroj: Nano Research. 15:9286-9297
ISSN: 1998-0000
1998-0124
DOI: 10.1007/s12274-022-4683-x
Popis: The potency of Toll-like receptor 9 (TLR9) agonist to drive innate immune response was limited due to immune suppression or tolerance during TLR9 signaling activation in immune cells. Herein we addressed this problem by introducing hydroxyapatite nanoparticles (HANPs) to CpG ODN (CpG), a TLR9 agonist. The study revealed that HANPs concentration and duration-dependently reprogramed the immune response by enhancing the secretion of immunostimulatory cytokines (tumor necrosis factor α (TNFα) or IL-6) while reducing the production of immunosuppressive cytokine (IL-10) in macrophages in response to CpG. Next, the enhanced immune response benefited from increased intracellular CaSupplementary material (TEM image, LDH activity, the Ca
Databáze: OpenAIRE
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