Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles
| Autor: | Jörg Kobarg, Ariadne Tuckmantel Bido, Ângela Saito, Mateus Borba Cardoso, Jessica Fernanda Affonso de Oliveira, Hubert Stassen |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Silver
Cell Survival medicine.drug_class Science Antibiotics Metal Nanoparticles 02 engineering and technology Biology 010402 general chemistry 01 natural sciences Article Silver nanoparticle Toxicology Drug Delivery Systems Antibiotic resistance Mitotic cell cycle Escherichia coli medicine Humans Metaphase Multidisciplinary Rational design Mesoporous silica Silicon Dioxide 021001 nanoscience & nanotechnology Antimicrobial Combinatorial chemistry Anti-Bacterial Agents 0104 chemical sciences HEK293 Cells Medicine Ampicillin 0210 nano-technology |
| Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-01209-1 |
| Popis: | The rational synthesis of alternative materials is highly demanding due to the outbreak of infectious diseases and resistance to antibiotics. Herein, we report a tailored nanoantibiotic synthesis protocol where the antibiotic binding was optimized on the silver-silica core-shell nanoparticles surface to maximize biological responses. The obtained silver nanoparticles coated with mesoporous silica functionalized with ampicillin presented remarkable antimicrobial effects against susceptible and antibiotic-resistant Escherichia coli. In addition, these structures were not cell-death inducers and different steps of the mitotic cell cycle (prophase, anaphase and metaphase) were clearly identified. The superior biological results were attributed to a proper and tailored synthesis strategy. |
| Databáze: | OpenAIRE |
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