Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood
| Autor: | Candice Z. Ulmer, Niklas Rye Jørgensen, Richard Eastell, Konstantinos Makris, Annemieke C. Heijboer, Harjit Pal Bhattoa, Etienne Cavalier, Cyrus Cooper, Samuel Vasikaran, Stuart L. Silverman, John A. Kanis |
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| Přispěvatelé: | Laboratory for Endocrinology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Clinical chemistry, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Clinical Biochemistry Osteoporosis Medical laboratory Bone resorption C-terminal telopeptide of type I collagen Biochemistry Procollagen Type I Collagen Type I Article Bone remodeling 03 medical and health sciences 0302 clinical medicine Treatment targets N-terminal telopeptide Internal medicine β-CTX medicine Humans Procollagen type I N-propeptide business.industry Biochemistry (medical) General Medicine medicine.disease Peptide Fragments Standardization Reference intervals 030104 developmental biology PINP Harmonization 030220 oncology & carcinogenesis Bone formation Bone Remodeling Peptides business Bone turnover markers Biomarkers Procollagen |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry, 515, 16-20. Elsevier Bhattoa, H P, Cavalier, E, Eastell, R, Heijboer, A C, Jørgensen, N R, Makris, K, Ulmer, C Z, Kanis, J A, Cooper, C, Silverman, S L & Vasikaran, S D 2021, ' Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood ', Clinica Chimica Acta, vol. 515, pp. 16-20 . https://doi.org/10.1016/j.cca.2020.12.023 Clin Chim Acta Clinica Chimica Acta, 515, 16-20. Elsevier |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2020.12.023 |
| Popis: | Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX. |
| Databáze: | OpenAIRE |
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