Homozygous α Thalassemia/HB G Philadelphia
| Autor: | Samuel Charaohe, Richard J. Rodeheffer, Robert R. L. Smith, Drew M. Pardoll, Brian Hjelle, Richard T. Jones, John A. Phillips |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
Mild anemia Genotype Hemoglobins Abnormal Thalassemia Clinical Biochemistry Biology hemic and lymphatic diseases medicine Humans Genetics (clinical) Aged Homozygote Biochemistry (medical) Hb G-Philadelphia DNA Restriction Enzymes Hematology medicine.disease Virology Globins Pedigree Oxygen Female Hemoglobin Chromosome Deletion |
| Zdroj: | Hemoglobin. 6:503-515 |
| ISSN: | 1532-432X 0363-0269 |
| Popis: | Microcytic red cells from a 70 year old Negro man with mild anemia contained only hemoglobin G-Philadelphia. Red cells from all of his children had low-normal MCV's, and contained 32-34 percent of the abnormal hemoglobin. Oxygen affinity of his blood and stability of his hemolysate were normal, suggesting that his mild anemia was not caused by the the abnormal hemoglobin. Restriction endonuclease analyses of DNA from the proband and his offspring showed that the alpha G-Philadelphia globin gene exists in only one copy per chromosome. The new gene was probably created by an unequal cross-over which deleted an alpha globin coding sequence (derived from one or both alpha globin genes), as well as some or all of the DNA sequence between those genes. |
| Databáze: | OpenAIRE |
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