The paradox of declining fertility but increasing twinning rates with advancing maternal age
| Autor: | Roel Schats, Roy Homburg, Peter G.A. Hompes, C.B. Lambalk, S.N. Beemsterboer, N.A. Gorter |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Ovulation Infertility Aging Dizygotic twin media_common.quotation_subject Fertility Biology Andrology Follicle Ovarian Follicle Pregnancy Follicular phase Twins Dizygotic medicine Humans Ovarian follicle media_common Rehabilitation Obstetrics and Gynecology medicine.disease medicine.anatomical_structure Reproductive Medicine Female Follicle Stimulating Hormone Pregnancy Multiple Infertility Female Maternal Age |
| Zdroj: | Human Reproduction. 21:1531-1532 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/humrep/del009 |
| Popis: | Advancing female age is associated with declining fertility potential due to decreasing numbers and quality of oocytes but also with a distinct increase in dizygotic twinning rates, a phenomenon that has never been explained.An analysis of follicle development was made in 959 spontaneous ovulatory cycles of 507 women.Multiple ovarian follicular development (1 follicle14 mm) and, by implication, multiple rather than single ovulations occurred in 105 women whose mean age (36.1 versus 34.6 years) and mean basal FSH concentrations (10.3 versus 7.7 IU/l) were significantly greater than those with monofollicular development (P0.01). The prevalence of multifollicular development increased with age.Dizygotic twinning must be associated with the development of1 large follicle, which we found to be a significantly more frequent occurrence in older women. It is hypothesized that the response of pituitary release of FSH to the decreased negative feedback induced by impending ovarian failure often 'overshoots', causing multiple follicular development. In the presence of two good-quality oocytes, a twin pregnancy may result. |
| Databáze: | OpenAIRE |
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