Anti-Cancer and Radio-Sensitizing Effects of Curcumin in Nasopharyngeal Carcinoma
| Autor: | Amirhossein Sahebkar, Muhammed Majeed, Amir Abbas Momtazi-Borojeni, Michele Caraglia, Faezeh Ghasemi, AmirReza Hesari |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Curcumin medicine.medical_treatment Context (language use) Antineoplastic Agents 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Radioresistance Drug Discovery medicine Humans Pharmacology Chemotherapy Biological Products Molecular Structure business.industry Head and neck cancer Cancer Nasopharyngeal Neoplasms medicine.disease Radiation therapy 030104 developmental biology chemistry Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Cancer research business |
| Zdroj: | Current pharmaceutical design. 24(19) |
| ISSN: | 1873-4286 |
| Popis: | Nasopharyngeal Cancer (NPC) is a rare type of head and neck cancer that is mainly treated by radiotherapy, but sometimes it is radioresistant. Curcumin is a polyphenolic natural product with established anticancer effects in various human cancers. Recent studies have shown that curcumin has therapeutic and radiosensitizing effects on NPC cells. In fact, it has been found that curcumin can sensitize NPC cells to radiation through different mechanisms, including modulation of ROS generation, Jab1/CSN5 and non-coding RNAs. As curcumin is safe and lacks systemic toxic effects in humans, it may be considered as a potential candidate to enhance the therapeutic effects of radiation and potentiate the efficacy of chemotherapy in the context of combination regimens. |
| Databáze: | OpenAIRE |
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