Upfront combination therapy reduces right ventricular volumes in pulmonary arterial hypertension
| Autor: | Martijn W. Heymans, Anton Vonk-Noordegraaf, Nico Westerhof, Mariëlle C. van de Veerdonk, J. Tim Marcus, Anna E. Huis In ‘t Veld, Harm-Jan Bogaard |
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| Přispěvatelé: | Cardiology, ACS - Pulmonary hypertension & thrombosis, Pulmonary medicine, Physics and medical technology, Physiology, APH - Personalized Medicine, APH - Methodology, Epidemiology and Data Science, APH - Quality of Care |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Endothelin Receptor Antagonists Male medicine.medical_specialty Cardiac Catheterization Combination therapy medicine.drug_class medicine.medical_treatment Heart Ventricles Hypertension Pulmonary 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Cardiac magnetic resonance imaging Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Cardiac catheterization Aged Netherlands Retrospective Studies medicine.diagnostic_test business.industry Stroke Volume Stroke volume Middle Aged Phosphodiesterase 5 Inhibitors Magnetic Resonance Imaging Peptide Fragments Surgery medicine.anatomical_structure 030228 respiratory system Ventricle Cardiology Vascular resistance Linear Models Ventricular Function Right Drug Therapy Combination Female Vascular Resistance business |
| Zdroj: | European Respiratory Journal, 49(6):1700007. European Respiratory Society van de Veerdonk, M C, in t Veld, A E H, Marcus, J T, Westerhof, N, Heymans, M W, Bogaard, H-J & Vonk-Noordegraaf, A 2017, ' Upfront combination therapy reduces right ventricular volumes in pulmonary arterial hypertension ', European Respiratory Journal, vol. 49, no. 6, 1700007 . https://doi.org/10.1183/13993003.00007-2017 |
| ISSN: | 0903-1936 |
| DOI: | 10.1183/13993003.00007-2017 |
| Popis: | In pulmonary arterial hypertension (PAH), upfront combination therapy is associated with better clinical outcomes and a greater reduction in N-terminal pro-brain natriuretic peptide (NT-proBNP) than monotherapy. NT-proBNP levels reflect right ventricular (RV) wall stress, which increases when the right ventricle dilates. This study explored the impact of upfront combination therapy on RV volumes compared with monotherapy in PAH patients.This retrospective study involved 80 incident PAH patients (New York Heart Association class II and III) who were treated with upfront combination therapy (n=35) (i.e. endothelin receptor antagonists (ERAs) plus phosphodiesterase-5-inhibitors (PDE5Is)) or monotherapy (n=45) (i.e. either ERAs or PDE5Is). All patients underwent right-sided heart catheterisation and cardiac magnetic resonance imaging at baseline and after 1-year follow-up.Combination therapy resulted in more significant reductions in pulmonary vascular resistance and pulmonary pressures than monotherapy. NT-proBNP was decreased by ∼77% in the combination therapy group compared with a ∼51% reduction after monotherapy (pIn PAH patients, upfront combination therapy was associated with improved RV volumes. |
| Databáze: | OpenAIRE |
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