Tissue ingrowth into perforated polymethylmethacrylate orbital implants: an experimental study
| Autor: | Denny Marcos Garcia, Gyl Eanes Barros Silva, Verônica Batista de Albuquerque, Antonio Augusto Velasco e Cruz, Denise Miyashita, Fernando Chahud |
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| Přispěvatelé: | Universidade de São Paulo (USP), University of State São Paulo |
| Rok vydání: | 2013 |
| Předmět: |
Male
COELHOS Neutrophils Dentistry Neovascularization Physiologic Biocompatible Materials Picrosirius red Prosthesis Implantation Collagen formation Medicine Animals Polymethyl Methacrylate New zealand white Lymphocytes Orbit Evisceration Cell Proliferation Connective Tissue Cells business.industry General Medicine Anatomy Ophthalmology Rabbit model Surgery sense organs Implant Collagen Rabbits business Clinical evaluation Porosity Tissue ingrowth Orbital implants Orbital Implants |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1537-2677 |
| Popis: | Made available in DSpace on 2022-04-29T08:44:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-05-01 Purpose: To evaluate the clinical response and fibrovascular ingrowth into perforated acrylic orbital implants in a rabbit model. Methods: Perforated implants were manufactured by drilling channels interconnected at the center in conventional 12- to 13-mm acrylic spheres. The implants were placed in 16 eviscerated eyes with posterior sclerotomy of 16 New Zealand white rabbits. Clinical evaluation was performed daily for the first 14 days after surgery and at 7-day intervals until the end of the study (180 days). Histopathologic analysis was performed at 14, 45, 90, and 180 days after implantation. Hematoxylin-eosin and picrosirius red staining was used to assess the inflammatory reaction and collagen formation. Results: There were no signs of infection, implant exposure, or extrusion in any animal during the study. Tissue ingrowth in the implant center was already detected by 14 days. At the end of the study, there was a dense collagen ingrowth with just a few inflammatory cells inside the implant. No multinucleated giant cells were found in any implant. Conclusions: Similar to porous implants, perforated acrylic implants permit fibrovascular ingrowth from surrounding orbital tissues. © 2013 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc. Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery Hospital das Clínicas-Campus University of São Paulo, Ribeirão Preto, 14049-900 São Paulo Department of Anesthesiology, Surgery Hospital das Clínicas-Campus University of State São Paulo, Araçatuba, São Paulo |
| Databáze: | OpenAIRE |
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