Localized and systemic scleroderma
| Autor: | J C English rd, A Hawk |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiac fibrosis Dermatology Systemic scleroderma Scleroderma Scleroderma Localized Anticentromere antibody positivity Fibrosis Pulmonary fibrosis medicine Humans Linear Scleroderma Child skin and connective tissue diseases Localized Scleroderma PUVA Therapy Bone Marrow Transplantation Skin Immunosuppression Therapy Scleroderma Systemic integumentary system business.industry Relaxin Calcium Channel Blockers Prognosis medicine.disease Photopheresis Prostaglandins Surgery business |
| Zdroj: | Seminars in Cutaneous Medicine and Surgery. 20:27-37 |
| ISSN: | 1085-5629 |
| DOI: | 10.1053/sder.2001.23093 |
| Popis: | Scleroderma is a broad term encompassing both localized and systemic sclerosis. Localized scleroderma is a cutaneous limited fibrosis that manifests as plaque morphea, generalized morphea, linear scleroderma, and deep morphea. Systemic scleroderma (sclerosis) can manifest as either limited or diffuse disease. Limited systemic sclerosis is typically preceded by Raynaud's phenomenon, involves cutaneous sclerosis distal to the elbows, with gastrointestinal and pulmonary fibrosis, and anticentromere antibody positivity. Diffuse systemic scleroderma is characterized by simultaneous Raynaud's phenomenon, cutaneous skin involvement proximal to the elbow with gastrointestinal, pulmonary, renal and cardiac fibrosis, and positive serology for antitopoisomerase and anti-RNAP III antibodies. This article discusses the classification, epidemiology, pathogenesis, clinical manifestations, treatment, and prognosis of the scleroderma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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